Table 2.
The most significant associations of single SNPs with heroin addiction
| SNP | Gene Symbol | HWE1 | Allele test |
Genotype test |
|
|---|---|---|---|---|---|
| P value | OR (95%CI) | P value | |||
| rs486179 | ADRA1A | 0.68 | 0.0077 | 1.56 (1.11, 2.18) | 0.0251 |
| rs3759292 | AVPR1A | 1.00 | 0.0083 | 0.16 (0.00, 0.76) | 0.0079 |
| rs971074 | ADH7 | 0.18 | 0.0035 | 1.94 (1.22, 3.14) | 0.0011 |
| rs2350780 | CHRM2 | 1.00 | 0.0066 | 1.61 (1.13, 2.30) | 0.0205 |
| rs2289948 | DBI | 0.66 | 0.0053 | 1.86 (1.18, 3.00) | 0.0156 |
| rs12613135 | DBI | 0.25 | 0.0077 | 1.54 (1.11, 2.13) | 0.0181 |
| rs5326 | DRD1 | 1.00 | 0.0029 | 1.94 (1.23, 3.12) | 0.0108 |
| rs7165224 | GABRB3 | 1.00 | 0.0057 | 1.64 (1.14, 2.36) | 0.0090 |
| rs2058725 | GAD1 | 0.03 | 0.0074 | 0.66 (0.47, 0.90) | 0.0050 |
| rs8190646 | GAD2 | 0.41 | 0.0066 | 1.81 (1.16, 2.87) | 0.0363 |
| rs1650420 | GRIN2A | 0.53 | 0.0006 | 1.68 (1.24, 2.27) | 0.0009 |
| rs4587976 | GRIN2A | 0.22 | 0.0039 | 1.56 (1.14, 2.14) | 0.0090 |
| rs6497730 | GRIN2A | 0.01 | 0.0015 | 0.62 (0.45, 0.84) | 0.0025 |
| rs1070487 | GRIN2A | 0.28 | 0.0022 | 1.58 (1.17, 2.15) | 0.0046 |
| rs1176724 | HTR3A | 1.00 | 0.0048 | 0.64 (0.47, 0.88) | 0.0170 |
| rs897687 | HTR3A | 1.00 | 0.0075 | 0.65 (0.47, 0.90) | 0.0265 |
| rs731780 | SLC29A1 | 0.47 | 0.0006 | 0.38 (0.21, 0.69) | 0.0004 |
SNPs are sorted by gene symbols.
1
Uncorrected Exact test values for deviation from Hardy-Weinberg Proportions in the control sample.