Fig. 4.
Rats underwent the 10-day RI protocol and were treated with the Akt inhibitor (5.8 mg·kg−1·day−1 ip), dominant negative Akt adenovirus (DN-Akt-Adv; 2 × 1012 plaque-forming units), or PP2 (3 mg·kg−1·day−1 ip) as shown. Bottom: coronary flow was measured in the CZ and NZ using radioactive microspheres during LAD occlusion and expressed as the ratio between CZ and NZ flows at day 10 of RI. Top: coronary flow was measured on days 0 and 10 of the RI protocol, and flow in the LAD-dependent zone (CZ) during LAD occlusion was expressed in milliliters per gram per minute.