Fig. 4.

A and B: relaxations of KCl-induced (60 mM; A) or phenylephrine-induced (2 μM; B) contractions in tail artery by menthol (filled bars) were significantly reduced (*P < 0.05, **P < 0.01, paired Student's t-test) after preincubation with (S)-BEL (100 μM) but not after preincubation with (R)-BEL (100 μM, open bars). Control KCl- and phenylephrine-induced contractions shown by hatched bars. C: raw data traces showing the control phenylephrine-induced contraction followed by the menthol-induced vasodilatation in at left and the loss of menthol-induced vasodilatation in the presence of (S)-BEL at right.