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. 2009 Apr 10;296(6):H1868–H1877. doi: 10.1152/ajpheart.01112.2008

Fig. 5.

Fig. 5.

Effects of menthol and ACh on human forearm cutaneous red cell flux. A: Vasodilatation after ∼10 min passive menthol application (3% solution; solid line). Blood flow from the vehicle control site (25% ethanol; dashed line) recorded simultaneously showed no such increase (*P < 0.05 and ***P <0.001, respectively, menthol vs. vehicle control, ANOVA for repeated measures). B: iontophoretic application of ACh (1% solution, 1 × 30 s at 70 μA; solid line, ⧫) caused a marked vasodilatation which was significantly attenuated by pretreatment with l-NAME (10 mM solution, 12 min, large dashes, □) or atropine (100 nM solution, 1 × 30 s at 70 μA; fine dashes, ▴). *P < 0.05 and **P < 0.01 levels for peak ACh response vs. peak response with l-NAME or atropine, paired Student's t-test. C: passive application of menthol (solid line, ⧫) caused a marked vasodilatation, which was significantly attenuated by pretreatment with l-NAME (10 mM solution, 12 min, large dashes, ▪) or atropine (100 nM solution, 1 × 30 s at 70 μA; fine dashes, ▴). †P < 0.05 and ***P < 0.001 levels at 30 min for menthol vs. l-NAME or atropine, respectively, ANOVA for repeated measures.