Table 1.
Endogenous compounds that are substrates for human MRP1–MRP9 and CFTR.
| Endogenous substrates | MRP1 | MRP2 | MRP3 | MRP4 | MRP5 | MRP6 | MRP7 | MRP8 | MRP9 | CFTR |
|---|---|---|---|---|---|---|---|---|---|---|
| GSH conjugates | X | X | X | X | X | X | X | X | ||
| Cysteinyl leukotrienes (e.g., LTC4) | X | X | X | X | X | X | X | |||
| Glucuronic acid conjugates | X | X | X | X | X | X | X | |||
| Bile salts | X | X | ||||||||
| Bilirubin | X | X | X | |||||||
| Estradiol, 17B- | X | X | X | X | X | X | ||||
| Sulfate conjugates | X | X | X | X | X | |||||
| Bile Salts | X | X | X | |||||||
| Sulfated Steroids | X | X | X | X | ||||||
| Cyclic nucleotides | X | X | X | |||||||
| GSH (+/− other substrates) | X | X | X | X | X | |||||
| GSSG | X | X | X |
Endogenous substrates for these proteins are indicated by (X); however, the absence of an (X) does not eliminate the possibility of transport for the given substrate, as this may have not yet been examined. Data were obtained from Borst et al., 2000, 2007; Ilias et al., 2002;Konig et al., 1999, Kruh et al., 2007a; Leslie et al., 2001b; Lindsell and Hanrahan, 1998; Rius et al., 2006, 2008; Wijnholds et al., 2000; Zelcer et al., 2003.