Strains |
F. tularensis LVS |
Attenuated F. tularensis vaccine strain |
CBER/FDA |
LVSΔguaA
|
F. tularensis LVS mutant in guaA locus |
This study |
LVSΔguaB
|
F. tularensis LVS mutant in guaB locus |
This study |
E coli DH5α |
deoR, endA1, gyrA96, recA1, relA1, supE44 |
Laboratory collection |
Plasmids |
pUC19 |
Cloning vector (Ampr) |
Laboratory collection |
pBlue-ScriptKS+ |
Cloning vector (Ampr) |
Laboratory collection |
pUCGA |
Containing guaA5′-aphT-guaA3′ cassette |
This study |
pBSGB |
Containing guaB5′-aphT-guaB3′ cassette |
This study |
pSacB |
Containing the sacB gene |
This study |
pFT695 |
guaA suicide plasmid |
This study |
pFT724 |
guaB suicide plasmid |
This study |
pFT906 |
Plasmid containing PguaB promoter |
This study |
PFT916 |
Plasmid containing PguaB-guaA fragment |
This study |
pKK214 |
Plasmid used to trans complement mutants |
UTSA |
pKK214guaA
|
pKK214 plasmid containing full-length guaA
|
This study |
pKK214guaB
|
pKK214 plasmid containing full-length guaA
|
This study |