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. Author manuscript; available in PMC: 2010 Apr 21.
Published in final edited form as: Vaccine. 2009 Mar 3;27(18):2426–2436. doi: 10.1016/j.vaccine.2009.02.073

Table 5. Protective immunity in vaccinated BALB/c mice to re-infection with F. tularensis LVS.

Vaccine Strain Immunization dose Survival ratioa Median time to death (days)
LVS ΔguaA
Group 6 9.0 × 102 4/5 >28
Group 8 9.0 × 104 5/5 >28
Group 10 9.0 × 106 5/5 >28
Group 11 9.0 × 107 4/4b >28
LVS ΔguaB
Group 12 1.05 × 102 0/5 5
Group 14 1.05 × 104 5/5 >28
Group 16 1.05 × 106 5/5 >28
Group 17 1.05 × 107 5/5 >28
Gelatin 0.1%-PBS
Group 18 None 0/5 5

Groups of BALB/c mice pre-vaccinated (see table 3) with 10 fold dilutions of LVSΔguaA (groups 6 to 11); LVSΔguaB (groups 12 to 17) and gelatin 0.1% - PBS (group 18) were injected with 2.5 × 103 CFU of parental LVS strain by intraperitoneal route.

a

Survival ratio, number of survival animal/ total number of animals immunized at day 28.

b

One mouse dead after the immunization with LVSΔguaA derivative strain