TABLE 2.
Effect of Terminalia chebula extract on the activities of lysosomal enzymes in the heart homogenate of control and experimental rats
| Group I (control) | Group II (isoproterenol injected) | Group III (T chebula) | Group IV (T chebula plus isoproterenol) | ANOVA F value | |
|---|---|---|---|---|---|
| Beta-D-glucuronidase* | 22.43±2.94 | 34.88±5.29§ | 23.23±3.29¶ | 25.36±3.18** | 13.69 |
| Beta-D-glucosidase* | 15.20±1.01 | 28.20±1.41§ | 15.12±1.03¶ | 19.39±0.58** | 204.74 |
| Beta-N-acetyl-glucosaminidase* | 47.64±4.42 | 67.63±7.89§ | 43.30±4.17¶ | 50.27±7.52** | 17.02 |
| Cathepsin D† | 28.75±3.88 | 46.34±3.75§ | 27.22±3.39¶ | 33.56±2.92** | 36.68 |
| Acid phosphatase‡ | 120.03±11.82 | 155.48±14.36§ | 113.52±12.00¶ | 135.48±14.36** | 4.53 |
Enzyme activity expressed in:
*
p-nitrophenol liberated (μmol/h/100 mg protein);
†
Tyrosine liberated (μmol/h/100 mg protein); and
‡
p-nitrophenol liberated (μmol/min/100 mg protein).
§
Significantly different compared with group I (P<0.01);
¶
Not statistically different compared with group I.
**
Significantly different compared with group II (P<0.01) (Bonferroni’s Multiple Comparison Test). Values are expressed as mean ± SD for six rats in each group