TABLE 3.
Myocardial reduced glutathione (GSH) and oxidized glutathione (GSSG) content in rat at 16 weeks postmyocardial infarction with and without vitamin E supplementation
| Animal group |
GSH (nmol/g tissue weight) |
GSSG (nmol/g tissue weight) |
GSH:GSSG |
|||
|---|---|---|---|---|---|---|
| LV | RV | LV | RV | LV | RV | |
| Basal diet | ||||||
| Control | 70.0±2.6 | 70.7±1.8 | 6.0±0.7 | 6.3±1.1 | 11.7 | 11.2 |
| MI | 37.4±3.4* | 59.6±3.0† | 30.5±2.2* | 16.3±2.2* | 1.2* | 4.0* |
| Vitamin E-supplemented diet | ||||||
| Control | 71.1±2.6 | 68.5±3.0 | 5.9±0.4 | 5.9±0.3 | 12.1 | 11.6 |
| MI | 65.3±5.0‡ | 65.5±1.6 | 8.0±1.1‡ | 5.9±0.7‡ | 8.2‡ | 11.1‡ |
*
Significantly different (P<0.05) from respective control group using ANOVA followed by Bonferroni’s test;
†
Significantly different (P<0.05) from respective control group using Student’s t test;
‡
Significantly different (P<0.05) from unsupplemented myocardial infarction (MI) group using ANOVA followed by Bonferroni’s test. Values are expressed as mean ± SEM for five rats. LV Left ventricle; RV Right ventricle