TABLE 1.
Autoantibodies directed against G-protein-coupled receptors in various diseases
| Receptor type | Disease | Prevalence (%) |
|---|---|---|
| Alpha1-R | Hypertension | 44 |
| β1-R | Dilated cardiomyopathy | 80 |
| β1-R | Myocarditis | 80 |
| β1-R | Chagas’ disease | 29 |
| β2-R | Chagas’ disease | 12 |
| β2-R | Allergic asthma | ND |
| AT1-R | Preeclampsia | 80 |
| AT1-R | Malignant hypertension | 14 to 33 |
| AT1-R | Vascular renal rejection | ND |
| Muscarinic M2-R | Chagas’ disease | 77 |
| Muscarinic M2-R | Dilated cardiomyopathy | 25 |
| 5HT4-R | Systemic lupus erythematosus | ND |
| Nicotinic AcCh-R | Myasthenia gravis | 90 |
| Glutamate receptor | Rasmussen’s encephalitis, noninflammatory focal epilepsy, catastrophic epilepsy | ND |
| TSH-R | Grave’s disease | >95 |
5HT4-R Serotonin receptor; β-R beta-Adrenergic receptor; AcCh-R Acetylcholine receptor; alpha-R alpha-Adrenergic receptor; AT1-R Angiotensin-II receptor 1; M2-R M2-receptor; ND No data available; TSH Thyroid stimulating hormone