Table 2.
Genes with the best Spearman's Rank Correlation between λ and expression measurements (p-values < 0.02). Genes in bold are in the GenAge database, known to be involved in aging. Stars indicate genes where evidence exists for involvement in aging, yet not appearing in the GenAge database
| Symbol | Gene name | p-value | Spearman's ρ |
|---|---|---|---|
| PPIC | peptidyl-prolyl isomerase c | 0 | −0.9182 |
| * CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 |
0.0025 | −0.8363 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0027 | −0.8667 |
| POLD1 |
Polymerase (DNA directed), delta 1, catalytic subunit |
0.0041 | 0.8091 |
| CES2 | carboxylesterase 2 | 0.0044 | −0.8091 |
| * MGMT | O-6-methylguanine-DNA methyltransferase | 0.0048 | 0.8 |
| CENTG2 | centaurin, gamma 2 | 0.0050 | 0.8303 |
| PNN | pinin, desmosome associated protein | 0.0056 | 0.7909 |
| HGF | hepatocyte growth factor | 0.0061 | −0.7909 |
| KLKB1 | kallikrein B, plasma 1 | 0.0061 | −0.7909 |
| POLG | Polymerase (DNA directed), gamma | 0.0061 | −0.7909 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 | 0.0062 | 0.8182 |
| ICT1 | immature colon carcinoma transcript 1 | 0.0065 | 0.7818 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0065 | 0.7818 |
| PUM2 | pumilio homolog 2 (Drosophila) [ | 0.0065 | 0.7818 |
| TNA | C-type lectin domain family 3, member b | 0.0070 | −0.7818 |
| HGD | Homogentisate 1,2-dioxygenase (homogentisate oxidase) |
0.0086 | 0.7636 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 |
0.0092 | −0.7636 |
| MAPK10 | mitogen-activated protein kinase 10 | 0.0098 | 0.7545 |
| PRC1 | protein regulator of cytokinesis 1 | 0.0108 | −0.8167 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0108 | −0.8167 |
| MMP15 | matrix metallopeptidase 15 | 0.0112 | 0.7454 |
| THRB | thyroid hormone receptor, beta | 0.0119 | −0.7454 |
| IL10RA | interleukin 10 receptor, alpha | 0.0126 | 0.7364 |
| GZMM | granzyme M | 0.0126 | 0.7364 |
| RGS9 | regulator of G-protein signalling 9 | 0.0126 | 0.7697 |
| GUCA1A | guanylate cyclase activator 1A | 0.0134 | −0.7364 |
| GFRA2 | GDNF family receptor alpha 2 | 0.0134 | −0.7364 |
| NEUROD1 | neurogenic differentiation 1 | 0.0134 | −0.7364 |
| UEV3 | UEV and lactate/malate dehyrogenase domains | 0.0135 | −0.7782 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0137 | −0.7697 |
| CRYZ | crystallin, zeta | 0.0138 | 0.8 |
| CLCN1 | chloride channel 1 | 0.0142 | 0.7273 |
| EIF3S6 | eukaryotic translation initiation factor 3, subunit 6 48kDa |
0.0142 | 0.7273 |
| MBNL1 | Muscleblind-like (Drosophila) | 0.0148 | 0.7576 |
| EHD1 | EH-domain containing 1 | 0.0148 | 0.7576 |
| PTX3 | pentraxin-related gene | 0.0150 | −0.7273 |
| P2RY2 | purinergic receptor P2Y | 0.0159 | 0.7182 |
| PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | 0.0159 | 0.7182 |
| POU5F1 | POU domain, class 5, transcription factor 1 | 0.0159 | 0.7182 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan |
0.0159 | 0.7182 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0168 | −0.7182 |
| CYB5 | Cytochrome b-5 | 0.0168 | −0.7182 |
| CSF1R | colony stimulating factor 1 receptor, | 0.0168 | −0.7182 |
| KIAA0101 | KIAA0101 | 0.0168 | −0.7182 |
| CYP2E1 | Cytochrome P450, family 2, subfamily E, polypeptide 1 |
0.0168 | −0.7182 |
| EXOC7 | exocyst complex component 7 | 0.0171 | 0.7454 |
| SRP68 | signal recognition particle 68kDa | 0.0172 | 0.7833 |
| CETN1 | centrin, EF-hand protein, 1 | 0.0177 | 0.7091 |
| NCL | Nucleolin | 0.0177 | 0.7091 |
| TERF2 | telomeric repeat binding factor 2 | 0.0177 | 0.7091 |
| CSNK1G2 | casein kinase 1, gamma 2 | 0.0197 | 0.7 |
| APOC4 | Apolipoprotein C-IV | 0.0197 | 0.7 |