Table 1.
List of miRNAs and their target gene involved in human breast cancer.
MicroRNA | Targets | Aberrant expression and roles | References |
---|---|---|---|
MiR-21 | BCL2, TPM1, PDCD4, PTEN | Overexpressed and play oncogenic role | [14–17] |
MiR-10b | Homeobox D10 | Down modulated, but associated with metastatic potential | [20] |
MiR-27a | ZBTB10 | Oncogenic role in breast cancer cells | [21] |
MiR-206 | ERα | Overexpressed | [22, 23] |
MiR-17-5p | AIB1 | Oncosuppressor in breast cell lines | [24] |
MiR-125a, miR-125b | ERBB2, ERBB3 | Down modulated and act as oncosuppressor | [9, 25] |
Let-7 | RAS, HMGA2 | Down modulated and reduced in BT-ICs | [26] |
MiR-205 | HER3 | Down modulated | [27] |