TABLE 4.

Functional Assignment for Proteins Identified as Increased by Egln1 Knockdown in VHL(−) Renal Carcinoma Cells

Protein	Function
ATP5B	Beta subunit of catalytic core of mitochondrial ATP synthase
ATP5A	Alpha subunit of catalytic core of mitochondrial ATP synthase
MRCL3	Myosin regulatory light chain 3
SLC25A5	Mitochondrial adenine nucleotide transporter promoting growth and proliferation; required for cancer cell glycolysis
SLC25A6	Mitochondrial adenine nucleotide transporter; dominantly stimulates apoptosis; participates in TNF-induced apoptosis
BASP1	Expressed in podocytes; transcriptional cosuppressor working with Wilms’ Tumor suppressor.
MYO1C	Unconventional myosin. Nuclear localization and association with RNA Polymerase I and II complexes in regulation of transcription association.
NUPL2	Nucleorporin, member of the nuclear envelope; participates in docking of the viral DNA
NDUFA5	B13 subunit of complex I of the mitochondrial respiratory chain located in the inner mitochondrial membrane
MYO1B	Actin binding; regulates intracellular trafficking of protein cargo in multivesicular sorting endosomes
ATP5O	Component of a the F-type ATP synthase in the mitochondrial matrix
ATAD3A	Component of mitochondrial nucleoids; binds to displacement loop in the major noncoding region
TOMM20	Translocase of outer mitochondrial membrane participating in recognition of pre-proteins.
UQCRH	Mitochondrial Hinge protein. Reduced expression in ovarian and breast cancer due to hypermethylation; break point gene in Ewing sarcoma.
SLC2A2	Glucose transporter 2, integral plasma membrane glycoprotein; glucose sensing
ATP5F1	Beta subunit of the proton channel of mitochondrial ATP synthase