Figure 5.

(a) Logarithm of the DOS g(E) for different degrees of hydrophobicity (ɛ = 0.0, 0.2, 0.4, 0.6, 0.8, and 1.0) and for the bulk case. Notice the abrupt decay of g(E) by ∼13 orders of magnitude as ɛ goes from 0.0 to 1.0. For high values of ɛ, the protein tends to be in the unfolded state. (b) Specific heat of the protein for different values of ɛ, 0.0, 0.2, 0.4, 0.6, 0.8, and 1.0, compared to the bulk case. T_f = 321 K is the transition temperature for the bulk. Notice how T_f and the peak of the specific heat decrease as ɛ goes from 0 (purely repulsive wall) to 1 (strongly attractive wall).