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Antiviral susceptibility of an HBV isolate cloned from a patient with lamivudine resistance. An HBV isolate amplified from the sera of patients failing in lamivudine therapy was cloned into the pHY106 vector and analyzed in vitro. Lane 1-4: transfected cells treated with 0.01, 0.1, 1 and 10 μmol/L of adefovir; Lane 5-8: transfected cells treated with 0.01, 0.1, 1 and 10 μmol/L of lamivudine.
