Table 1.

Summary of measured deuterium number incorporated into each Aβ reporter peptide from different aggregated states

Fragment	Total exchangeable protons	Corrected deuterium number
		Monomer∗	LMW∗	HMW†	Fibril‡
1-16	15	15.2 ± 0.4	15.2 ± 0.4	14.7 ± 0.3	8.2 ± 0.3
1-19	18	18.0 ± 0.4	18.0 ± 0.4	15.6 ± 0.4	8.8 ± 0.3
20-33	13	12.8 ± 0.3	7.7 ± 0.3	5.7 ± 0.2	5.2 ± 0.1
20-34	14	13.9 ± 0.3	8.6 ± 0.3	5.9 ± 0.3	5.5 ± 0.1
23-34	11	10.8 ± 0.3	7.8 ± 0.4	5.7 ± 0.2	5.4 ± 0.3
34-40	6	5.7 ± 0.1§	4.0 ± 0.1¶	3.9 ± 0.1	3.9 ± 0.1
35-40	5	4.8 ± 0.1§	3.7 ± 0.1¶	3.6 ± 0.1	3.7 ± 0.1
20-40	19	19.9 ± 0.2	11.8 ± 0.4	8.9 ± 0.3	8.6 ± 0.3

Uncertainties are based on the SD triplicates.

^∗Aβ(1-40) monomer and LMW oligomers from fresh sample, labeled for 10 s.

^†Spherical HMW oligomers from 4-h aged samples, labeled for 1 h.

^‡Washed fibrils from 6-day aged sample, labeled for 24 h.

^§Values determined from 1 h labeled fresh sample.

^¶Value determined from calculation by Eq. 7.