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Structural mapping of cancer mutations and modeling protein stability effects in the MET kinase. Protein stability differences between the WT RET and RET mutants using CUPSAT (A), FOLDx (B), and MM-GBSA (C). Mapping of cancer mutations into the structure of the RET kinase (D). Negative values of protein stability changes correspond to destabilizing mutations. Mutational sites are in green CPK Ca models. Mutations with the largest destabilization effect are shown in red.
