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The RMSD values for Cα atoms from 20-ns simulations with the inactive RET kinase (A) and the active RET kinase. (C) The RMSF values of the RET kinase residues (using original numbering in the PDB entries 1XPD and 2IVS) from 20-ns MD simulations with the inactive RET kinase (B) and the active RET kinase (D). For all panels, time evolution of the WT RET is shown in blue; time evolution of the M918T RET mutant is shown in red.
