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(A) The average structure of the ACTIVE form of WT RET kinase with M918 residue shown in CPK model. (B) A closeup of structural packing near the mutational site in the ACTIVE WT RET kinase. (C) The average structure of the ACTIVE form of M918T RET kinase mutant with T918 residue shown in CPK model. (D) A closeup of structural packing near the mutational site in the ACTIVE T918 RET kinase.
