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. 2009 Feb 4;96(3):858–874. doi: 10.1016/j.bpj.2008.10.041

Figure 7.

Figure 7

Analysis of MD simulations with the inactive MET kinase. Time evolution of the distances between Ca atoms of the residues in the local structural environment of the mutational site. Time evolution of the distances between Ca atoms of the M1250T MET and L1245 MET (A), M1250T MET and V1257 MET (B), M1250T MET and S1254 MET (C), and M1250T MET and F1260 MET (D). Time evolution of the distances for the M1250 WT MET is shown in blue; time evolution of the distances for the T1250 MET mutant is shown in red.