Table 2.
Clinical and Hemodynamic Characteristics*
| Variables | Case Subjects (n = 30) | Control Subjects (n = 109) | p Value |
|---|---|---|---|
| Age, yr | 54 ± 10 | 53 ± 9 | 0.55 |
| Female gender | 20 (67) | 43 (40) | 0.008 |
| Race | 0.24 | ||
| White | 28 (93) | 97 (89) | |
| Black | 0 | 8 (7) | |
| Other | 2 (7) | 4 (4) | |
| Etiology of portal hypertension | |||
| Alcohol | 13 (43) | 48 (44) | 0.95 |
| Hepatitis C infection | 5 (17) | 57 (52) | 0.001 |
| Autoimmune hepatitis | 7 (23) | 4 (4) | 0.002 |
| Nonalcoholic fatty liver disease | 1 (3) | 8 (75) | 0.68 |
| Hepatitis B infection | 1 (3) | 6 (6) | 1.0 |
| Primary sclerosing cholangitis | 1 (3) | 9 (8) | 0.69 |
| Primary biliary cirrhosis | 3 (10) | 3 (3) | 0.12 |
| Cryptogenic | 2 (7) | 8 (7) | 1.0 |
| Model for End-stage Liver Disease score† | 12 ± 3 | 13 ± 5 | 0.86 |
| Echocardiography | |||
| RV dilation | 24 (80) | 0 | 0.001 |
| RV hypertrophy‡ | 11 (39) | 0 | 0.001 |
| RV dysfunction | 17 (59) | 0 | 0.001 |
| RV systolic pressure,§ mm Hg | 77 ± 26 | 31 ± 5 | 0.001 |
| Invasive hemodynamics | |||
| Mean right atrial pressure,‖ mm Hg | 9 ± 6 | ||
| Mean pulmonary artery pressure, mm Hg | 50 ± 9 | ||
| Pulmonary capillary wedge pressure, mm Hg | 10 ± 4 | ||
| Cardiac index, L/min/m2 | 2.9 ± 0.9 | ||
| Pulmonary vascular resistance, dyne · s · cm–5 | 672 ± 376 |
*Variables are given as the mean ± SD or No. (%), unless otherwise indicated.
†Data available for 28 case patients and 108 control subjects.
‡Data available for 28 case patients and 104 control subjects.
§Right ventricular systolic pressure estimable in 27 case patients and 45 control subjects.
‖Mean atrial pressure was measured in 29 case patients.