Table III . Proteins identified in both patient and control samples that had been previously suggested as autoantigens in other studies.

These proteins were reported in the literature as potential disease-associated antigens. They had previously been identified using approaches in which cell extracts, first separated by two-dimensional electrophoresis and blotted, were probed with patient serum, and immunoreactive spots were excised for mass spectrometry. None of them are membrane proteins. hnRNP, heterogeneous nuclear ribonucleoprotein.

Possible autoantigen	Number in patient precipitates (total = 3)	Number in control precipitates (total = 3)	Disease	Ref.
Ribonucleoprotein hnRNP-A2/B1	3	3	Autoimmune hepatitis	Huguet et al. (8)
Ribonucleoprotein hnRNP-A1	3	3	HTLV-1-associated myelopathy	Levin et al. (17)
Heat shock protein HSP70	3	2	Hepatitis C	Fukuda et al. (18)
Tubulin	1	1	Relapsing polychondritis	Tanaka et al. (19)
Tubulin	1	1	Allergic rhinitis	Nakamura et al. (20)
Tubulin	1	1	Acute leukemias	Cui et al. (7)
Actin	1	1	Hepatitis C	Fukuda et al. (18)
Actin	1	1	Rheumatoid arthritis	Matsuo et al. (21)
Actin	1	1	Acute leukemias	Cui et al. (7)