Table 3.

Association of IL-18 promoter polymorphism in populations with different diseases and disease severity

Disease	Position	Population	Outcome	Reference
HIV	−607	Brazilian	Associated	[13]
Rheumatoid arthritis	−607, −137	309 Polish	Associated	[24]
Type 1 diabetes	−607	112 Iranians	No association	[25, 26]
Allergic rhinitis	−607	160 Korea	Associated	[27]
Crohn’s disease	−607, −137	210 German	Association	[11]
Behcet’s disease	−607, −137	98 Korea	No association	[28]
Sarcoidosis	−607, −137	161 Japanese	No association	[29]
Periodontitis	−607	123 German	No association	[30]
Cardiovascular disease	−137	1288 French	Associated	[12]
Atopic eczema	−137	225 German	Associated	[31]
Inflammatory bowel disease	−137	178 Japan	Associated	[32]