MT-I+II inhibitory actions
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| MT-I+II scavenge and neutralize ROS |
| MT-I+II inhibit pro-inflammatory cytokines, macrophages and T-lymphocytes. |
MT-I+II inhibit apoptosis (incl. cytochrome-c leakage, p53 levels, caspase activity)
|
MT-I+II stimulatory actions
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| MT-I+II augment anti-inflammatory and neuroprotective parameters in CNS |
| MT-I+II increase mitogens, apoptosis-inhibitory genes and growth/trophic factors |
MT-I+II promote functional recovery including neurogenesis
|
MT-I+II homeostatic regulation
|
| MT-I+II control and regulate toxic and essential metals |
| MT-I+II regulate NFkB concentration and activity |
