Table 2.

MCM5 and HPV oncoprotein expression.

MCM5
MCM5 overexpression may be due to the release of Rb inhibition on transcription factor E2F due to binding of HPV E7 oncoproteins E2F may bind to the MCM5 promoter to increase transcription of MCM5 MCM5 mRNA expression increase significantly with increasing severity of dysplasia