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. 2007 Feb 7;1:215–225.

Table 4.

p16INK4A and HPV oncoprotein expression.

p16INK4A

  • Inactivation of Rb by HPV E7 protein may up-regulate p16INK4A

  • p16INK4A may be directly induced by the transcription factor E2F released from pRb after binding of HPV E7

  • An HPV-independent pathway for p16INK4A up-regulation many also exist