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Identification of the IFN-beta promoter region responsible for activation by HCV NS5B protein. Three luciferase reporter plasmids with different lengths of IFN-beta promoter region, deleting PRD IV (bp −97 to +19), PRD III (bp −84 to +19), or PRD I (bp −71 to +19), were co-transfected with pCXN2-HA-NS5B. The normalized luciferase activities were calculated by assigning a value of 1 to the levels of activity of cells that were transfected with the empty vector. *P < 0.05
