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Effect of HCV proteins on TRIF-induced activation of IFN-beta. HepG2 cells were co-transfected with pEF-BOS-myc-TRIF, pGL3-p125 luc, and expression plasmids for the six HCV proteins, core protein, NS2, NS3, NS4A, NS4B, and NS5A. The normalized luciferase activities were calculated by assigning a value of 1 to the levels of activity of cells that were transfected with the empty vector. *P < 0.05 compared with the activity of the cells with the vector plus TRIF
