Table 2.

Treatment options after NA failure

Resistance to	Treatment options
Lamivudine	Add adefovir
	Add tenofovir
	Switch to tenofovir plus emtricitabine (fixed-dose combination)
	Switch to entecavir
Adefovir	Add lamivudine
	Add entecavir
	Switch to entecavir
	Switch to tenofovir plus emtricitabine (fixed-dose combination)
	Switch to entecavir (if no lamivudine resistance)
Entecavir	Add adefovir
	Add tenofovir
	Switch to adefovir
	Switch to tenofovir
Telbivudine	Add adefovir
	Add tenofovir
	Switch to emtricitabine
	Switch to tenofovir