Table 1.
Body weight and biochemical parameters of the plasma and liver in SD- and HCD-fed mice at the end of the feeding period
| Parameter/marker | Mean ± SEM* | P | |
|---|---|---|---|
| Standard diet | HCD | ||
| Body weight (g) | 30.1 ± 0.3** | 38.8 ± 1.2** | <0.05 |
| Glucose (mM) | 9.3 ± 0.25 | 14.0 ± 0.75 | <0.001 |
| ALT (mU mL−1) | 28.3 ± 3.0 | 31.2 ± 2.9 | NS |
| Free fatty acids (plasma, mEq dL−1) | 0.50 ± 0.02 | 0.33 ± 0.021 | <0.001 |
| Cholesterol (plasma, mg dL−1) | 36.4 ± 0.86 | 67.4 ± 2.6 | <0.001 |
| Insulin (pg mL−1) | 582 ± 54 | 2,037 ± 360 | <0.001 |
| Triacylglycerols (liver, mg g−1) | 60.2 ± 6.7 | 159.4 ± 14.6 | <0.001 |
| Triacylglycerols (plasma, mg dL−1) | 101.0 ± 9.8 | 92.9 ± 8.3 | NS |
| TBARS (nmol g−1 wet weight) | 90.4 ± 14.5 | 170.9 ± 16.8 | <0.010 |
| TNF-α (pg mL−1) | 40.3 ± 13.4 | 37.6 ± 18.7 | NS |
| Adiponectin (ng mL−1) | 23.7 ± 0.48 | 23.2 ± 2.0 | NS |
* Means ± SEM were calculated for 5 animals in each group
** The initial body weight was 23.5 ± 0.8 g (n = 10)