Table 1.
Demographic characteristics of the patients
| Characteristic | Total patients (n = 423) | VBT (n = 123) | Non VBT (n = 300) | P valuea |
|---|---|---|---|---|
| Age (years) | 30.8 ± 12.9 | 28.7 ± 11.6 | 31.6 ± 13.4 | 0.059 |
| Male, n (%) | 367 (86.8) | 99 (80.5) | 268 (89.3) | 0.018 |
| HBeAg positive, n (%) | 261 (61.7) | 81 (65.9) | 180 (60) | 0.273 |
| Log ALT, U/l | 2.0 ± 0.2 | 2.0 ± 0.2 | 2.0 ± 0.2 | 0.698 |
| Log HBV DNA, copies/ml | 7.8 ± 1.4 | 8.1 ± 1.4 | 7.1 ± 1.4 | 0.005 |
| Mean duration of treatment, months | 24.8 ± 13.7 | 35.9 ± 13.6 | 20.3 ± 10.9 | 0.001 |
| Cirrhosis, n (%) | 28 (6.6) | 6 (4.9) | 22 (7.3) | 0.399 |
Note: VBT, viral breakthrough was defined as >1 log10 copies increase in HBV DNA from nadir after an initial virologic response or HBV DNA could be detected again after the previous report of under the detection limit [7]
aP values were determined by student's t test and chi-square test