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HBV polymerase mutations associated with antiviral resistance in vitro and in vivo [29]
| Antiviral agent | Mutations documented to confer resistance |
|---|---|
| Lamivudine | rtM204V |
| rtM204I | |
| rtL180M | |
| ADV | rtN236T |
| rtA181T | |
| rtA181V | |
| Entecavir | rtL180M + rtM204V + rtT184G + rtS202I |
| rtL180M + rtM204V + rtI169T + rtM250V | |
| Telbivudine | rtM204I |
| rtM204V + rtL180M |
