Figure 3.

Time course changes of inflammatory cell infiltration in skin wounds in wild-type (WT), MMP-9 KO, MMP-13, and MMP-9/13 double KO mice. Neutrophils (A), macrophages (B), and T lymphocytes (C) were identified by immunohistochemistry with anti-neutrophil antibody, anti-CD68 antibody and anti-CD3 antibody, respectively. Immunoreactive inflammatory cells/mm² were determined by counting immunostained cells in 6 different areas in the wounds on days 0.5, 1, 3, 5, and 7 (n = 3). Bars = mean ± SE.