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. 2009 Aug;175(2):533–546. doi: 10.2353/ajpath.2009.081080

Figure 7.

Figure 7

Time-course changes of angiogenesis in skin wounds. A: Immunohistochemistry of CD31 in skin wounds in wild-type (WT), MMP-9 KO, MMP-13, and MMP-9/13 double KO mice. Paraffin sections of skin wounds on day 5 were subjected to immunohistochemistry. Scale bar = 500 μm. Higher magnifications of the boxed areas in the wounds of wild-type, MMP-9 KO, MMP-13 KO, and MMP-9/13 double KO mice are shown in the lower panels. Scale bar = 50 μm. B: Time-course changes of vascular density/mm2 on days 0, 3, 5, 7, 10, 14, and 28 determined by counting numbers of CD31-positive vessels within six visual fields (n = 3). *P < 0.05; **P < 0.01.