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IGFBP-5 induces ECM and α-SMA production in a MAPK-dependent and IGF-I-independent manner. A: Fibroblasts were stimulated with 500 ng/ml IGFBP-5 or vehicle following a 1-hour incubation with MEK inhibitor U0126 or DMSO as a vehicle control. B: Fibroblasts were treated as in A following a 1 hour incubation with neutralizing anti-IGF-I antibody. ECM and α-SMA expression were analyzed by Western blot.
