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. 2009 Aug;175(2):627–635. doi: 10.2353/ajpath.2009.081081

Figure 5.

Figure 5

Induction and IGF-1R regulation of major stress pathways associated with cholestatic liver injury. Liver samples were collected from Sham or BDL, control and LIGFREKO mice on postoperative day 3 and were examined. A: JNK activation determined by western blotting for p-JNK and total JNK protein. Blots are representative of groups of 5 animals. B: GRP78 expression measured by RT-QPCR. C: CHOP expression determined by Western blot (upper, representative blot) and RT-QPCR (lower). D: Bax expression measured by RT-QPCR. Data were normalized to 18S rRNA and represent means ± SEM for 5 to 8 animals. *P < 0.05; **P < 0.01; ***P < 0.005. E: eIF2α activation determined by Western blot analysis of p-eIF2α and total eIF2α proteins. Blots are representative of groups of 5 animals.