TABLE 4.

−3A/−4A endothelin-1 (ET-1) genotype and allelic distribution according to smoking status in normotensive and hypertensive groups

	Smokers 1				Nonsmokers
−3A/−4A ET-1 genotype	−3A−3A	−3A−4A	−4A−4A	−3A	−3A−3A	−3A−4A	−4A−4A	−3A
Normotensives (n=173)	34	36	8	0.66	43	43	9	0.68
Men (n=78)	20	18	2	0.73	14	19	5	0.62
Women (n=95)	14	18	6	0.61	29	24	4	0.72
Hypertensives (n=196)	49	35	4	0.76*	51	48	9	0.69
Men (n=111)	34	24	1	0.78**	19	27	6	0.63
Women (n=85)	15	11	3	0.71	32	21	3	0.76†

^*P<0.05 versus normotensives smokers 1;

^†P<0.05 versus male nonsmokers;

^**P<0.01 versus male nonsmokers. Smokers 1 are those who had smoked at least seven cigarettes a week for at least one year at any time in their life