Table 3.
Familial Aggregation of 31 Autoimmune Diseases† in Denmark
| Disease in cohort member | Odds Ratio (95% Confidence Interval) | ||
|---|---|---|---|
| History of the given disease in: | |||
| Parents or Sibs | Parents | Sibs | |
| Thyrotoxicosis | 3.4 (3.1-3.6) | 2.9 (2.6-3.1) | 5.2 (4.6-6.0) |
| Thyroiditis* | 13.9 (9.8-19.6) | 9.2 (5.7-14.6) | 30.1 (18.2-49.7) |
| Type I Diabetes | 4.0 (3.8-4.2) | 3.0 (2.9-3.2) | 8.8 (8.3-9.4) |
| Other Adrenal Gland* | 68.4 (43.9-106.7) | 29.3 (13.9-62.1) | 205.4 (123.1-342.7) |
| Intestinal Malabsorption* | 53.0 (44.0-63.8) | 41.8 (32.5-53.9) | 83.2 (66.0-104.9) |
| Pernicious Anemia* | 16.2 (9.9-26.6) | 12.5 (7.0-22.4) | 57.4 (23.3-141.3) |
| Acquired Hemolytic Anemia* | 3.6 (0.5-25.8) | 15.2 (2.1-108.4) | |
| Purpura | 22.9 (19.4-27.0) | 22.8 (18.2-28.6) | 32.0 (26.4-38.8) |
| Multiple Sclerosis | 6.0 (5.2-6.7) | 5.3 (4.5-6.3) | 7.1 (5.8-8.8) |
| Guillain Barre Syndrome | 2.3 (1.3-4.1) | 1.7 (0.8-3.5) | 5.0 (2.1-12.1) |
| Uveitis | 3.3 (2.6-4.2) | 2.9 (2.1-4.0) | 4.1 (3.0-5.8) |
| Wegener’s Granulomatosis | |||
| Crohn’s Disease | 5.4 (4.8-6.0) | 5.1 (4.3-5.9) | 5.7 (4.9-6.6) |
| Ulcerative Colitis | 4.4 (4.1-4.8) | 4.1 (3.7-4.6) | 5.0 (4.5-5.6) |
| Primary Biliary Cirrhosis (90%)* | 31.5 (9.9-100.2) | 35.0 (11.0-111.4) | |
| Chronic Active Hepatitis* | 8.3 (5.1-13.4) | 5.3 (2.6-10.6) | 16.8 (8.7-32.6) |
| Interstitial Cystitis | 1.7 (1.6-1.9) | 1.6 (1.4-1.7) | 2.2 (2.0-2.5) |
| Endometriosis* | 2.3 (2.1-2.5) | 1.9 (1.7-2.2) | 2.8 (2.5-3.2) |
| Pemphigoid* | 23.1 (9.5-56.1) | 32.6 (13.4-79.4) | |
| Pemphigus | |||
| Psoriasis | 7.5 (6.7-8.5) | 7.3 (6.3-8.4) | 8.6 (7.1-10.5) |
| Alopecia Areata* | 22.7 (13.1-39.4) | 10.7 (3.4-33.4) | 33.6 (18.0-63.0) |
| Vitiligo* | 7.9 (4.1-15.2) | 5.1 (1.7-15.9) | 10.8 (4.8-24.3) |
| Seropositive Rheumatoid Arthritis | 3.4 (3.0-3.8) | 3.0 (2.6-3.4) | 5.9 (4.7-7.4) |
| Dermatomyositis* | 3.9 (0.6-27.7) | 4.9 (0.7-35.2) | |
| Myositis | 2.2 (2.1-2.4) | 2.1 (1.9-2.2) | 2.6 (2.3-2.9) |
| Polymyalgia Rheumatica | 3.6 (2.2-5.7) | 3.6 (2.2-6.0) | 3.2 (0.8-12.8) |
| Myasthenia Gravis* | 78.5 (49.7-124.1) | 92.7 (57.3-149.8) | 91.3 (40.4-206.4) |
| Scleroderma* | 7.2 (2.3-22.6) | 2.9 (0.4-20.9) | 26.2 (6.5-105.5) |
| Systematic Lupus Erythematosis* | 18.1 (11.7-28.0) | 5.8 (2.4-14.0) | 48.9 (29.5-81.1) |
| Sjogren’s Syndrome* | 12.8 (7.0-23.3) | 14.8 (8.1-27.0) | 16.6 (4.1-67.1) |
†
ICD definitions of Diseases as categorized as Table 1.
*
Less than five co-occurring cases in the family expected on the hypothesis of no association