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. 2009 Jun 17;29(24):7753–7765. doi: 10.1523/JNEUROSCI.1794-09.2009

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Copyright © 2009 Society for Neuroscience 0270-6474/09/297753-13$15.00/0

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Figure 8. — Effects of RGS11 mutation on cone isolated, dark-adapted ERG. A, Schematic showing the protocol for deriving the cone-driven dark-adapted ERG. A high energy conditioning flash (3.0 log sc td, 250 ms duration) for the fully dark adapted condition was used to suppress rods fully and cones partially. Test flashes (1.9 log sc td s) presented at 750 ms from the termination of the conditioning flash probed for cone-only responses. Gray trace, RGS11 mutant; black trace, heterozygous littermate control. The responses for the conditioning flash were subtracted from paired flash response to yield responses for the test flash only. B, Averaged high-energy test-flash (1.9 log sc td s) responses (n = 6, each for RGS11 mutant: gray traces; littermate control: black) show a delayed leading and trailing edge of the b-wave for the RGS11 mutants. The RGS11 mutant b-wave amplitudes were greater than controls.