Maximum grade of toxicities by age decade is illustrated for both arms combined because the rates of AEs were similar in both arms. Patients are separated into age decades of less than 40 (light blue bars), 40 to 49 (dark red bars), 50 to 59 (gray bars), 60 to 69 (bright blue bars), 70 to 79 (gold bars), and ≥ 80 years old (dark blue bars).