Table 3.
Clinical and laboratory history of genital HPV infection during pregnancy and delivery and distribution of HPV types in maternal, newborns and children in 1st and 6th and 12th month of life samples.
| Maternal epidemiology | HPV type in samples | ||||||||||
| Pregnancy | Delivery | Maternal | Newborn | Children | |||||||
| Buccal | |||||||||||
| Case | HPV lesion type | HPV lesion site | Type | HPV lesion | Genital | Nasopharyngeal aspirates | Buccal and body | Cord blood | 1st month of life | 6th month of life | 12th month of life |
| 1 | Warts | VV | V | No | 6/11 | ||||||
| 2 | HGSIL | C | C | No | 16+6/11 | 6/11 | 6/11 | ||||
| 3 | HGSIL | C | C | Yes | 16+31 | ||||||
| 4 | Warts | VV | V | No | 16+42+54 | 42 | |||||
| 5 | LGSIL | C | C | Yes | 18 | ||||||
| 6 | Warts | VV | C | No | 6/11+16+31 | ||||||
| 7 | Warts | C+VV+VG | V | No | 6/11+42 | 6/11 | 6/11 | ||||
| 8 | HGSIL | C | C | Yes | 52 | 6/11 | |||||
| 9 | LGSIL | C | V | Yes | 42+51+NC* | ||||||
| 10 | Warts | VV+VG | V | No | 6/11 | ||||||
| 11 | LGSIL | C | V | No | 18 | 18 | 18 | ||||
| 12 | Warts | VV | V+F | No | NC* | ||||||
| 13 | LGSIL | C | C | Yes | 6/11+42 | ||||||
| 14 | LGSIL | C | C | Yes | 16+42+58 | 59 | |||||
| 15 | Warts | C+VV+VG | V | Yes | 6/11+42 | ||||||
| 16 | Warts | VV+VG | C | No | 6/11 | 6/11 | |||||
| 17 | HGSIL | C | C | Yes | 18+51 | ||||||
| 18 | Warts | VV+P | C | No | 42+59 | ||||||
| 19 | Warts | VV | V | No | 6/11 | ||||||
| 20 | HGSIL | C | C | No | 42+35 | ||||||
| 21 | Warts | VV | C | Yes | 52 | 52 | |||||
| 22 | Warts | VV | C | Yes | 34 | ||||||
| 23 | Warts | VV+VG | V | Yes | 18 | ||||||
| 24 | Warts | VV | V | No | 16+73 | ||||||
| 25 | Warts | VV+VG | C | No | 68 | ||||||
| 26 | Warts | C | V | Yes | 6/11+16 | 16 | |||||
| 27 | Warts | C+VV+VG | V | No | 16+58 | ||||||
| 28 | Warts | VV | C | Yes | 6/11+33 | ||||||
| 29 | LGSIL | C | V | No | 16 | ||||||
| 30 | LGSIL | C | V | Yes | 52+42+58+54 | ||||||
| 31 | LGSIL | C | C | No | 16 | ||||||
| 32 | Warts | VV | C | No | 6/11 | ||||||
| 33 | HGSIL | C | V | Yes | 18 | ||||||
| 34 | Warts | VV | V | Yes | 11 | 11 | |||||
| 35 | Warts | VV+VG | C | Yes | 42 | 42 | |||||
| 36 | LGSIL | C | V | Yes | 16 | ||||||
| 37 | HGSIL | C | C | Yes | 58 | 6/11+52 | 6/11 | ||||
| 38 | HGSIL | C | V | No | 6/11+18 | 6/11 | |||||
| 39 | HGSIL | C | C | Yes | 18+31 | ||||||
| 40 | Warts | VV | V | No | 6/11 | ||||||
| 41 | Warts | VV | C | No | 42+35+NC* | ||||||
| 42 | LGSIL | C | C | Yes | 42 | ||||||
| 43 | LGSIL | C | C | Yes | 16+18+42 | ||||||
| 44 | LGSIL | C+VV+VG | C | Yes | 18+26 | ||||||
| 45 | Warts | VV | V | Yes | 6/11+58+59 | 6/11 | 6/11 | ||||
| 46 | Warts | VV+VG | C | Yes | 6 | ||||||
| 47 | Warts | VV | V | Yes | 35 | ||||||
| 48 | Warts | VV | V | No | 70 | ||||||
| 49 | Warts | VV+VG | V | No | 6+45 | 6/11+52 | |||||
| 50 | LGSIL | C | V | Yes | - | ||||||
| 51 | Warts | VV | C | No | - | ||||||
| 52 | HGSIL** | C | C | Yes | - | ||||||
| 53 | Warts | VV+VG | C | Yes | - | ||||||
| 54 | HGSIL | C | V | Yes | - | ||||||
| 55 | LGSIL | C | V | Yes | - | ||||||
| 56 | HGSIL | C | V | Yes | - | ||||||
| 57 | HGSIL | C | V | No | - | ||||||
| 58 | HGSIL | C | C | No | - | ||||||
| 59 | HGSIL | C | C | Yes | - | ||||||
| 60 | LGSIL | C | V | No | - | ||||||
| 61 | HGSIL | C | V | Yes | - | ||||||
| 62 | LGSIL | C | C | Yes | - | ||||||
| 63 | HGSIL | C | V | Yes | - | ||||||
The HPV types were identified by both multiplex PCR and nested multiplex PCR methods.*NC = HPV-DNA positive but could not be classified by type. **Child had anogenital warts (HPV type 6/11) in the 12th month of life.
Delivery type = C – cesarean section; V- vaginal; and V+ F – vaginal with forceps.
HPV lesion site = C – cervical; VG – vaginal; VV – vulva; P- perineal.
HPV lesion type = Warts – genital warts; LGSIL – low-grade squamous intraepithelial lesions; HGSIL – high-grade squamous intraepithelial lesions.