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. Author manuscript; available in PMC: 2009 Jul 28.
Published in final edited form as: J Comp Neurol. 2009 May 10;514(2):161–173. doi: 10.1002/cne.22004

Figure 1.

Figure 1

Some opV placode cells are post-mitotic by HH8 (3–5ss). A–C. All cells are labeled in embryos treated with 3H-Thy at HH7 (1ss) (collected at HH13 (18ss)). A. High power of opV placode cell (arrowhead) delaminating at mid-midbrain (mMB) level. B–C. At rostral hindbrain levels (rHB), spurs of cells delaminating from ectoderm were actively dividing at HH7 (arrowhead). D. Diagram of HH12 (15ss) embryo showing relative location of HH8 (4ss) post-mitotic cells in ectoderm (red circles) and mesenchyme (green triangles). E–I. Embryos treated with 3H-Thy at HH8 (4ss) (collected at HH12 (15ss)). E. Cluster of cells (arrows) have exited cell cycle by HH8 (4ss) at caudal forebrain level. F–G. Individual cells at rostral midbrain level have exited cell cycle and are delaminating. H. At mMB, a cell in ectoderm has exited the cell cycle (arrow). I. At rHB, most cells are labeled; a spur of opV cells actively dividing at HH8 (arrowhead). A–C, E–I. Large arrows indicate post-mitotic cells and arrowheads indicate cells in S phase at time of initial 3H-Thy. ECTO=ectoderm, NT=neural tube. Scale bars are approximately 10 µm.