C(α) atoms of the LFA seed residues located in the catalytic region and in the helical domain of EF–(2Ca-CaM), together with their associated clusters (residual correlation greater or equal to 0.03), represented in spheres: (a) Gln-376, (b) Leu-465, (c) Gly-429, (d) Gly-638, (e) Ser-682, and (f) Asn-675. Catalytic residues are displayed in licorice. The terms (L) and (R) stands for the left side and right side of the catalytic site, respectively. Colors follow the residual correlation profile with respect to each considered seed residue, from red down to blue.