Table 2.
Residues numbers delimiting 1), the EF-CaM domains in the structural biology definition by Drum et al. (20); and 2), the EF-CaM pseudodomains in the new definition with the LFA method
| Structural biology definition (20) | LFA definition | |||
|---|---|---|---|---|
| EF | CA | 294–349 and 490–622 | CA | 292–345 and 490–501 and 576–622 |
| Switch A | 502–551 | SA | 502–575 | |
| Switch B | 578–591 | |||
| CB | 350–489 | CB | 346–489 | |
| Switch C | 630–659 | SC | 623–659 | |
| Hel | 660–767 | Hel | 660–767 | |
| CaM | N-CaM | 5–64 | N-CaM | 5–84 |
| Interlinker | 65–92 | |||
| C-CaM | 93–147 | C-CaM | 85–147 | |
Residues involved in the catalytic site of EF are Arg-329 (L), Lys-346 (R), Leu-348 (R), His-351 (R), Lys-353 (R), Ser-354 (R), Lys-372 (R), Asp-491, Asp-493 (L), Thr-548 (L), His-577 (L), Thr-579 (L), Asp-582 (L), Asn-583 (L), Phe-586 (L), and Glu-588 (L) and belong either to the left side (L) or to the right side (R) of the site.