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. 2009 Feb 18;96(4):1374–1387. doi: 10.1016/j.bpj.2008.10.054

Figure 1.

Figure 1

(A) Amino acid sequence of a portion of the pore-forming region of the mouse RyR2 channel. E4832 and D4833 (highlighted in bold) are in close proximity to the series of residues equivalent to the selectivity filter in K+ channels. (B) Pore models of WT and ED4832AA RyR2 channel tetramers. The luminal faces of the models are shown in the upper panels and side views of the models are shown in the lower panels. In both cases the bulk of the structure is shown as ribbons with E4832 and D4833 in the WT and A4832 and A4833 in ED4832AA in CPK.