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. 2009 Feb 18;96(4):1374–1387. doi: 10.1016/j.bpj.2008.10.054

Figure 2.

Figure 2

Effects of caffeine (A) and caffeine and ryanodine (B) on Ca2+ release from intracellular stores in HEK cells transfected with the ED4832AA mutant. Fluorescence of Fluo-3 AM loaded cells was monitored continuously before and after addition of increasing concentrations of caffeine, or 0.25 mM caffeine (denoted C), 100 μM ryanodine and 2.5 mM caffeine (denoted C'). Traces shown are from a representative experiment that has been repeated three times. Similar responses were measured in all three experiments.