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. 2009 Feb 18;96(4):1586–1596. doi: 10.1016/j.bpj.2008.11.017

Figure 1.

Figure 1

Pairwise sequence alignment of Ice-CA and BCAII. The identical (asterisk) and similar (double points) residues are highlighted. In particular, the direct ligands His-94–His-96–His-119 (magenta), the proton shuttling residues Gly-63–His-64–Ser-65–Phe-66 (green), the binding site Val-121–Val-143–Leu-197–Trp-208 (yellow), the indirect zinc ligands Gln-92–Glu-117–Thr-199–Asn-243 (gray), and the aromatic cluster Phe-93–Phe-95–Trp-97 (cyan) are spotlighted (numeration valid for BCAII). The N-term and C-term regions that form the upper part of the enzyme (“knot” topology) are underlined in blue and yellow, respectively.