Table 1.

Summary of shear studies

Experiment No.	q∗ (/nm)	Slope (before shear)	Slope (after shear)
1	0.55	−2.74	−0.87
2	0.63	−2.29	−0.9
3	0.60	−2.94	−0.7
4	0.66	−2.81	−0.96
5	0.50	−1.93	−0.53
6	0.70	−1.76	−0.81

Fluid shear was applied on VWF in six independent runs, experiment 1 in Fig. 2 and experiments 2–6 in Fig. S1. The q value, above which scattering intensity increased (q^∗), was measured. Change in scattering intensity slope at q = q^∗ was also quantified before (0/s) and after shear application. Postshear results are presented at G = 3000/s in all experiments except for experiment 3, in which the maximum applied G was 1500/s.