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. 2009 Mar 18;96(6):2237–2244. doi: 10.1016/j.bpj.2008.12.3909

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© 2009 by the Biophysical Society.

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Possible effects of R146G and R146W mutations on the distribution of actin states in the presence (Ca²⁺) and absence (0) of calcium. In WT filaments, the equilibrium favors state i₀ in the absence of calcium and a Ca²⁺ in the presence of calcium. (A) Two-state model with inactive (i) and active (a) states. (B) Three-state model with inactive (i), intermediate (x), and active (a) states. The heavy arrows show the changes in equilibrium constants required to explain the results of the mutants.