Table 2.

Parameters for the three-state SERCA model generated from the optimization process

Parameter	Value
k1+	25,900 mM−1 s−1
k2+	2540 s−1
k3+	20.5 s−1
k1−	2 mM−1 s−1∗
k2−	67,200 mM−1 s−1
k3−	149 mM−1 s−1
Kd,Cai	0.91 mM
Kd,Casr	2.24 mM
Kd,H1	1.09 × 10−5 mM
Kd,Hi	3.54 × 10−3 mM2
Kd,Hsr	1.05 × 10−8 mM2
Kd,H	7.24 × 10−5 mM
n	2.0

^∗k₁⁻ is constrained by detailed balance (see Methods) and is dependent on the kinetic and dissociation constants of the model (see Appendix).